Spain faces world champions Italy in the tournament's last quarter-final showdown with its dangerous duo of David Villa and Fernando Torres.
The Spanish side have never beaten the Italians in a major tournament outside the Olympics.
While Spanish coach Luis Aragone's team have won all three matches in their group, Italy have dropped down into the last eight. They lost 3-0 to the Dutch in their first group match and scraped a 1-1 draw with Romania before beating 10-man France 2-0.
This evening's winner will face Russia in Wednesday's semi-final match.